Autoimmune diseases Slfohtiot rare diseases, antibody mediated. Recognize the antigens and autoanti

Autoimmune diseases Slfohtiot rare diseases, antibody mediated. Recognize the antigens and autoantibodies know are really not just a marker of pathogenic only (as opposed to that found in 170 lupus antibodies but no one knows what causes the disease from them if at all). Classification: 1 intra-epidermal-diseases best whitening toothpaste are among Hkrtnotzitim antigens in the epidermis, ie desmosomes. Loose bladder is usually only part of the epidermis is in the air while the BM remains intact and called raw of tumb stones. Dojo this one disease pemphigus vulgaris. 2 Afirameliot-grandfather disease antigen that is, between the dermis epidermis against Hmidsmozum. Blisters epidermis firmness that all air . example bolus in BP. mechanism: antibody against Mulk, Adhizih best whitening toothpaste between each cell and cell dermis, created Akntolizis best whitening toothpaste and blisters that become packed and painful ulcers (eg oral cavity) and skins. know what antigen of any disease. diagnosis: do a biopsy under local anesthesia, there is a knife to punch bipsy , drill a hole of about 4 mm and sent to pathology and above all IF. Normal pathology in BP it seems transmitted diseases epidermal turned all the air epidermis, pemphigus, intra-epidermal disease remained glued to the bottom line dermis. It is possible to do this IF- Hslfohtiot disease test (test): Direct IF on tissue taken, it is assumed that attached to antibodies against the bleached-linkage. Paint the tissue antibodies against human antibodies and fluorescent antibody authors. We'll get the antibody is connected to a tissue (usually (IgG and location of the connection. Indirect IF- Atzmoniim assume a patient antibodies in blood, serum takes its various antibodies authors best whitening toothpaste monkey epidermis best whitening toothpaste and check whether there rise. Mouth dilution can be done well, and discover the titers. ELISA , Imunnoblotting Immunoprecipitation research primarily. pemphigus vulgaris Afidmilogy: pemphigus rare disease of 1 in 1000 and hard. involves the skin and mucous membranes. crutch, age between 40-60, but can be any age, more common in Ashkenazi Jews. etiology: unknown. Theories: 1 2 antibodies Contact protein degradation in cells that are important best whitening toothpaste for immune tolerance 3 viral infection response of the immune system brings specificity Cross reactions 4 5 drugs / vaccines genetic predisposition: HLA2-DR4
Pathogenesis: the Hkrtnotzitim authors desmosomes are composed best whitening toothpaste of many proteins. There Dsmoglainim, they glycoproteins including Dsmoflkin, Flkoglovin. Pemphigus antigen it Dsmoglain-binding glycoprotein that ca: Dsmoglain 3, weighs 160 pounds Dalton, found primarily mucosa. best whitening toothpaste Dmsulgdlain one especially skin weight 130 kilodaltons.
Evidence of autoimmunity: 1. Passive transfer of auto antibodies- taken antibodies from patients, isolated them and injected them into mice neonates without causing an immune system disease which-has peeling and blistering of the skin and a classic image of pemphigus biopsy and IF. It is an autoimmune disease proof. 2 passive testing of cow Riebsorbtzih-taking Dsmoglain three columns with antibodies annex, transfer the serum of patients and prevent the disease. 3 Colrtzih with ELISA and IF Titr- indirect measures Teeter. When the disease is low and calm Teeter Teeter Cshmhlh active high. 4 Neonetal pemphigus- infant born with blisters and it will pass after a few wk. The reason best whitening toothpaste for such antibodies cross placenta IgG. 5 Response to treat autoimmune mirror (Aimonosofrsih treatment, Plasmapheresis, IVIG) are currently 6 knockout mice are Ldsmoglain three disease best whitening toothpaste develop more proof
How antibodies cause disease? Not clear. Think that intracellular processes: an increase in IP3 and intracellular calcium, activation best whitening toothpaste of PKC and PLC Plasminogen Activator factors causing the release of activity and destruction Hdsmoglain Frotalitit and Hstlfhot. Ie bind antibodies against Dsmoglain flogged, Hadhizih and cause cascades. Tried to do all sorts of manipulations on the intracellular best whitening toothpaste cascade but it is not delayed Hfrotaulizh of desmosomes. As long as antibodies best whitening toothpaste are created to be blisters. This means a treatment they object. Role of T cells in the pathogenesis of antigen presentation importance of B cells that produce antibodies. A complementary role, not essential to the development of the disease, but enough that antibodies have a role in pemphigus vulgaris-Classification: 1 lesions only mouth-3 antibodies Dsmolgain mainly in the mucous membranes and the skin does not exist. 2 lesions in the mouth and lesions in the skin of anti Dsmoglain 1 and 3. 3 superficial pemphigus (Foliaceus) - antibodies only against Dsmoglain one so therefore only be skin disease (because it's desmosomes common antigen but not desmosomes up of mucous) 4 pemphigus Franeoflsti-very severe lesions in the mouth and skin. Always accompanies malignant form and it is very difficult to involvement of the mucous membranes especially best whitening toothpaste in the tongue, severe involvement of the skin. Here casualties coated internal systems mainly squamous epithelial lung (30-40% of patients). Their prognosis 90-95% best whitening toothpaste of them will die of lung injury. This is usually malignancies hematologic cell B as Non-Hodgkin's lymphoma, CLL, and Castleman's disease., Less common sarcoma and Timomh. It the only way damaged epithelium inside the lungs. Antibodies against Dsmoglainim and against Flkin desmosomes and against Hmidsmozomim. 5 . bolus Amftigo-infectious disease especially in children, skin blisters due to bacteria Stfilokok. turned out its toxin crosses the Hdsmoglain 1, thereby causing the bladder. best whitening toothpaste Clinic: The disease usually begins in the mouth ulcers, it was not a straight diagnosed disease that there are many things that cause mouth ulcers such as herpes. Their blisters quickly become loose and erosions. Has a prevalence of scalp and facial involvement but everywhere. Has named Nikolsky sign-ill Active scratched the skin near the skin blister disconnected. Treatment: a bad disease responds to treatment, but severe treatments to patients must not give up. As long as Christians antibodies would be sick, aim to stop the production of antibodies. Easy-to-moderate disease: steroid-problematic drug that reduces the inflammation processes